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American Journal of Epidemiology Vol. 130, No. 3: 481-485
Copyright © 1989 by The Johns Hopkins University School of Hygiene and Public Health

research-article

COFFEE CONSUMPTION AND MYOCARDIAL INFARCTION IN WOMEN

CARLO LA VECCHIA1,2,, ANTONELLA GENTILE1, EVA NEGRI1, FABIO PARAZZINI1 and SILVIA FRANCESCH3

1"Mario Negri" Institute for Pharmacological Research Milan, Italy.
2Institute of Social and Preventive Medicine, University of Lausanne Switzerland.
3Aviano Cancer Center, Aviano, Pordenone Italy.

Reprint requats to Dr. Carlo La Vecchia, "Mario Negri" Institute for Pharmacological Research, Via Eritrea 62, 20157 Milan, Italy.

The relation between coffee consumption and the risk of acute myocardial infarction was evaluated in a hospital-based casecontrol study conducted in northern Italy between 1983 and 1987. The study consisted of 262 women with acute myocardial infarction and 519 controls admitted to the hospital for acute, nondigestive tract disorders. Information was obtained on the average number of cups of coffee or decaffeinated coffee consumed per day before the onset of the disease which led to hospital admission and on the total duration in years of the habit There was a positive association between heavy coffee drinking and risk of myocardial infarction (relative risk (RR) = 2.7 for consumption of four cups or more per day). After allowance for smoking and other relevant covariates, the relative risk was not elevated for consumption of up to three cups per day, but still above unity for consumption of four or more cups per day (RR = 1.7), and the multivariate trend in risk was still significant (x12 = 5.14, p = 0.02). The risk estimates were grossly elevated among hyperiipidemic women (multivariate RR = 7.6 for moderate and 17.9 for heavy coffee drinkers). As a result of small absolute numbers, these estimates were largely unstable and the interaction between coffee and hyperiipidemia was not statistically significant Such estimates, nonetheless, are of potential interest in terms of etiologic correlates and implications for prevention.

caffeine; cholestero; coffee; myocardial infarction; women


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