American Journal of Epidemiology Vol. 130, No. 2: 309-318
Copyright © 1989 by The Johns Hopkins University School of Hygiene and Public Health
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RETROVIRAL INFECTIONS (HIV-1, HIV-2, AND HTLV-I) IN RURAL NORTHWESTERN TANZANIA CLINICAL FINDINGS, EPIDEMIOLOGY, AND ASSOCIATION WITH INFECTIONS COMMON EN AFRICA
CLINICAL FINDINGS, EPIDEMIOLOGY, AND ASSOCIATION WITEI INFECTIONS COMMON IN AFRICA
1Department of Neurology, University Hospital of Innsbruck Innsbruck, Austria
2Institute of Medical Chemistry and Biochemistry, University of Innsbruck Innsbruck, Austria
3Ludwig Boltzman Institute for AIDS Research Innsbruck, Austria
4Institute of Hygiene, University of Innsbruck Innsbruck, Austria
5Nyakaiga Hospital Karagwe District, Bukoba Region, Tanzania
Reprint requests to Dr. Erich Schmutzhard, Universitäts-Klinik Fü Neurologie, Anichstrasse 35, A-6020 Innsbruck, Austria
During a three-wedc period in March/April 1987, the authors examined 253 consecutive patients referred to a rural hospital In northwestern Tanzania. Sera were tested for antibodies to human immunodeficiency virus type 1 (HIV-I), human immunodeficiency virus type 2 (HIV-2), and human T-lymphotropic virus type I (HTLV-I), as well as for various parasites, hepatitis B virus, and Trepormma pallldom. Neopterin (urinary and serum) was chosen as the Immunologic parameter. In eight of the 253 patients (3.2%), a clinical diagnosis of acquired immunodeflciency syndrome (AIDS) was established. Three of the AIDS patients had HIV-1 antibodies, two had HIV-1 antigen, one had both HIV-1 and HIV-2 antibodies, and in one patient, only HIV-2 antibodies were found. The total HIV-1 and HIV-2 seroprevalence (antibodies plus antigen) was 4.3%; HTLV-I seroprevalence was 9.9%. No correlation could be found between HIV (or HTLV-I) seropositivity and raised levels of antibody to the above pathogens. There was, however, a significantly positive correlation between HIV seroposttivtty and history of gonorrhea, whereas a history of operations, injections, vaccinations, blood transfusions, or scarification did not influence the level of HIV seropositivity. The most frequently noted epidemiologic association with HIV seropositivity was traveling to or coming from Uganda or Rwanda. Two thirds of the d i e d Tanzanians had elevated neopterin levels, and all seven HIV-seroposttive patients with clinical signs of AIDS had extremely high serum and urinary neopterin levels compared with HIVseropositive patients without signs of AIDS. Increased neopterin levels reflect a stimulation of the T-cell/macrophage system.
acquired immunodeficiency syndrome; HIV; HIV seropositivity; human T-cell leukemia virus; retrovirus infections
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