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American Journal of Epidemiology Vol. 129, No. 6: 1232-1246
Copyright © 1989 by The Johns Hopkins University School of Hygiene and Public Health

research-article

THE TUCSON CHILDREN'S RESPIRATORY STUDY

II. LOWER RESPIRATORY TRACT ILLNESS IN THE FIRST YEAR OF LIFE

ANNE L. WRIGHT1,, LYNN M. TAUSSIG1, C. GEORGE RAY1,3, H. ROBERT HARRISON1,3, CATHARINE J. HOLBERG1 and THE GROUP HEALTH MEDICAL ASSOCIATES 4

1Department of Pediatrics, Division of Respiratory Sciences, University of Arizona Tucson, AZ
2Department of Pathology, Division of Respiratory Sciences, University of Arizona Tucson, AZ
3Current address: Sandy Springs Pediatric Clinic Atlanta GA

Reprint requests to Dr. Anne Wright, Department of Pediatrics, University Medical Center, Tucson, AZ 85724

Lower respiratory tract illnesses occurring during the first year of life in 1,179 healthy infants enrolled in the Children's Respiratory Study, Tucson, Arizona, are described. The children, who use the pediatricians of a health maintenance organization, were enrolled into the study between May 1980 and January 1984. Data were collected on signs, symptoms, and diagnosis for each illness; nasopharyngeal and throat swabs were collected at the acute visit for viral, chlamydial, and mycoplasmal cultures. The cumulative incidence of illness in the first year of life was 32.88 per 100 children. Of the 348 initial lower respiratory tract illnesses occurring in these infants, 60% were diagnosed as bronchiolitis. At least one infecting agent was identified in 66% of the specimens collected at the time of the first illness. Respiratory syncytial virus was the most common isolate; 12 other agents were also identified. There was a strong (p < 0.0001) relation between agent identified, symptoms reported, and diagnosis; bronchiolitis was predominantly associated with respiratory syncytlal virus and croup with parain fluenza viruses. Sex and ethnicity were unrelated to illness experience or to characteristics of the first illness. Lower respiratory tract illness occurrence in the Children's Respiratory Study appears to be similar to patterns observed elsewhere, suggesting that diagnoses (and infecting agents) have changed little over the past decades.

bronchlolitis; viral; infant; prospective studies; respiratory syncytial viruses; respiratory tract infections; sex characteristics

4Group Health Medical Associates includes Drs. John Bean, John Curtiss, John Ey, Robert Moss, James Rothschild, Alejandro Sanguinetti, Barbara Smith, Sandra Smith, Terry Vondrak; and Maureen McLellan.


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