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American Journal of Epidemiology Vol. 129, No. 6: 1219-1231
Copyright © 1989 by The Johns Hopkins University School of Hygiene and Public Health

research-article

THE TUCSON CHILDREN'S RESPIRATORY STUDY

I. DESIGN AND IMPLEMENTATION OF A PROSPECTIVE STUDY OF ACUTE AND CHRONIC RESPIRATORY ILLNESS IN CHILDREN

LYNN M. TAUSSIG1,, ANNE L. WRIGHT1, WAYNE J. MORGAN1, H. ROBERT HARRISON1,2, C. GEORGE RAY1,3 and THE GROUP HEALTH MEDICAL ASSOCIATES 4

1Department of Pediatrics, Division of Respiratory Sciences, University of Arizona Tucson, AZ
2Current address: Sandy Springs Pediatric Clinic Atlanta, GA
3Department of Pathology, Division of Respiratory Sciences, University of Arizona Tucson, AZ

Reprint requests to Dr. Lynn M. Taussig, Depart ment of Pediatrics, Arizona Health Sciences Center, Tucson, AZ 85724

The Tucson Children's Respiratory Study, Tucson, Arizona, has been established as a long-term, longitudinal, prospective study of the risk factors for acute lower respiratory tract illnesses in early childhood and for chronic obstructive airways disease in later life. A total of 1,246 newborns were enrolled into the study between May 1980 and January 1984, representing 78% of eligible infants. Cord blood for immunologic studies, neonatal blood specimens for blood counts and differentials, and blood specimens at nine to 15 months of age for immunologic studies, blood counts, and differentials have been obtained on the majority of enrolled children. Pre-illness physiologic and more detailed immunologic studies have also been done on large subgroups of subjects. The majority of lower respiratory tract illnesses suffered by these children in the first three years of life have been assessed in detail for etiologic agents by means of culture and serologic techniques; 1,052 illnesses have been evaluated thus far. The type of illness and nature of etiologic agents are very similar to those reported in other epidemiologic studies. Thus, this group of enrolled infants and their family members constitute an appropriate population for the long-term study of risk factors for acute and chronic respiratory disorders.

epidemiologic methods; longitudinal studies; lung diseases; obstructive; prospective studies; respiratory tract infections

4Group Health Medical Associates includes Drs. John Bean, John Curtiss, John Ey, Robert Moss, James Rothschild, Alejandro Sanguinetti, Barbara Smith, Sandra Smith, Terry Vondrak; and Maureen McLellan.


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