American Journal of Epidemiology Vol. 129, No. 5: 973-987
Copyright © 1989 by The Johns Hopkins University School of Hygiene and Public Health
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THE RELATION BETWEEN PONDEROSITY AND CORONARY RISK FACTORS IN CHILDREN AND THEIR RELATIVES
THE MUSCATINE PONDEROSITY FAMILY STUDY
1Department of Preventive Medicine and Environmental Health, Division of Biostatistics, University of Iowa Iowa City, IA
2Departments of Epidemiology and Human Genetics, University of Michigan Ann Arbor, MI
3Departments of Pediatrics, Division of Pediatric Cardiology, and Preventive Medicine and Environmental Health, Division of Epidemiology, University of Iowa Iowa City, IA
Reprint requests to The Muscatine Study, Division of Pediatric Cardiology, W139 General Hospital, University of Iowa Hospitals and Clinics, Iowa City, IA 52242
A family study was conducted in Muscatine, Iowa in 1984–1985 to evaluate the relation between ponderosity in children and coronary risk factor levels in these children and in their family members, and the genetic contribution to familial clustering of levels of ponderosity (body weight relative to height). Four groups of probands were selected from the 1,783 students who participated in three consecutive biennial school surveys. A random group (n = 70), a random sample of students from the entire pool; a lean group (n = 72), students in the lowest quintile of relative weight on all three surveys; a gain group (n = 70), students who gained at least two quintiles of relative weight over the four-year period; and a heavy group (n = 72), students in the highest quintile of relative weight on all three surveys. The parents, siblings, a related aunt or uncle, and a first cousin of these probands were also examined. The data show that levels of high density lipoprotein (HDL) cholesterol, apolipoproteins A-I and B, and systolic blood pressure in heavy group probands are consistent with increased coronary risk. This same association exists among the relatives with excess ponderosity. Levels of body mass index in the mothers, fathers, and siblings cluster with the levels in the probands, and genetic differences among persons explain 36–52 per cent of the variability in body mass index across the range of ponderosity represented by the probands and their relatives. While the contribution from genes is strong, these data suggest that the contribution from environmental factors is equally as important.
blood pressure; body weight; family characteristics; lipids; lipoproteins; obesity; pedigree; variation (genetics)
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