American Journal of Epidemiology

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American Journal of Epidemiology Vol. 129, No. 5: 1000-1011
Copyright © 1989 by The Johns Hopkins University School of Hygiene and Public Health

research-article

EPIDEMIOLOGY OF VERTEBRAL FRACTURES IN WOMEN

L. JOSEPH MELTON, III^1,, STEPHEN H. KAN¹, MARK A. FRYE², HEINZ W. WAHNER³, W. MICHAEL O'FALLON¹ and B. LAWRENCE RIGGS²

¹Mayo Clinic and Foundation, Department of Health Sciences Research Rochester, MN
²Mayo Clinic and Foundation, Division of Endocrinology/Metabolism and Internal Medicine Rochester, MN
³Mayo Clinic and Foundation, Section of Diagnostic Nuclear Medicine, Department of Diagnostic Radiology Rochester, MN

Reprint requests to Dr. L. Joseph Melton, III, Section of Clinical Epidemiology, Department of Health Sciences Research, Mayo Clinic, 200 First Street SW, Rochester, MN 55905

Vertebral fracture prevalence was assessed in an age-stratified random sample of Rochester, Minnesota women aged 50 years and over. Vertebral fractures, including wedge and concavity as well as compression fractures, were common and increased with age. The estimated incidence of new vertebral fractures also rose with age, reaching 29.6 per 1,000 person-years in women aged 85 years. The prevalence of one or more vertebral fractures also increased with declining bone mass, reaching 42% in women with spinal bone mineral density less than 0.6 g/cm² by dual photon absorptiometry. Bone mass and age contributed independently to the risk of vertebral fracture, but "age" may reflect other manifestations of osteoporosis.

cross-sectional studies; osteoporosis; risk

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