American Journal of Epidemiology Vol. 129, No. 3: 511-517
Copyright © 1989 by The Johns Hopkins University School of Hygiene and Public Health
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HEART DISEASE RISK FACTORS, DIABETES, AND PROSTATIC CANCER IN AN ADULT COMMUNITY
1Department of Community and Family Medicine, University of California San Diego, La Jolla, CA
2Departments of Community and Family Medicine and Medicine, University of California San Diego, La Jolla, CA
3Cancer Center, and Department of Community and Family Medicine, University of California San Diego La Jolla, CA
Reprint requests to Dr. Elizabeth Barrett-Connor, Department of Community and Family Medicine M-007, University of California San Diego, La Jolla, CA 92093
The authors studied the association between heart disease and prostatic cancer in Rancho Bemardo, California, from August 1972 to June 1987. During a 14-year follow-up of 1,776 men aged 50–84 years, 100 cases of prostatic cancer were identified, of which 54 were incident Systolic blood pressure, cigarette smoking, and plasma cholesterol levels in cases did not differ from those In noncasea. After adjustment for age and on multivariate analysis, incident cases of prostatic cancer had a nonsignificantly higher frequency of reported heart disease at baseline. History of diabetes was inversely associated with total prostatic cancer (age-adjusted estimated relative risk = 0.2, 90% confidence interval: 0.0–0.8; multivariate-adjusted relative risk = 0.3, 90% confidence interval: 0.1–1.0). The association between heart disease and prostatic cancer is compatible with diagnostic detection bias. The inverse association between diabetes and prostatic cancer is compatible with a cancer-promoting role for endogenous testosterone, the level of which is lower in diabetics, or a risk-reducing effect of antidlabetic diet or drug therapy.
cardiovascular diseases; diabetes mellitus; nutrition; prostatic neoplasms
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