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American Journal of Epidemiology Vol. 129, No. 1: 212-219
Copyright © 1989 by The Johns Hopkins University School of Hygiene and Public Health

other

A COMPUTER PROGRAM FOR INCIDENCE DENSITY SAMPLING OF CONTROLS IN CASE-CONTROL STUDIES NESTED WITHIN OCCUPATIONAL COHORT STUDIES

JAMES J. BEAUMONT1,2,, KYLE STEENLAND1, ANN MINTON3 4 and SANDY MAYER3

1Industrywide Studies Branch, National Institute for Occupational Safety and Health Cincinnati, OH
2Current affiliation: Northern California Occupational Health Center, Division of Occupational and Environmental Medicine, University of California Davis, CA
3Dynalectron Corporation Cincinnati, OH

Address for reprints: James J. Beaumont, Division of Occupational and Environmental Medicine, Uni versity of California, Davis, CA 95616.

Beaumont, J. J. (U. of California, Davis, CA 95616), K. Steenland, A. Minton, and S. Meyer. A computer program for incidence density sampling of controls in case-control studies nested within occupational cohort studies. Am J Epidemiol 1989;129:212–19.

A nested case-control study Is a case-control study performed with a cohort study. The nested case-control design is useful because the number of study subjects for whom risk factor Information is needed Is smaller than in the original cohort study. The approach is especially helpful when collection of data Is expensive or time consuming, as when It is necessary to contact subjects or next of kin. Selection of controls in nested case-control studies is best performed with a method called "incidence density" sampling. An approach to Incidence density sampling that yields a valid estimate of the rate ratio Is sampling without replacement from noncases at the time of case occurrence. To implement this approach, a system of computer programs was written that randomly selects a user defined number of controls for each case. The case-control data produced by this program can be analyzed by conditional logistic regression.

epidemiologic methods; prospective studies; retrospective studies

4Current affiliation: Battelle Laboratory, Columbus, OH.


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