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American Journal of Epidemiology Vol. 129, No. 1: 146-154
Copyright © 1989 by The Johns Hopkins University School of Hygiene and Public Health

other

THE QUESTION OF CLUSTERING OF CREUTZFELDT-JAKOB DISEASE

RICHARD F. RAUBERTAS1, PAUL BROWN2,, FRANÇOISE CATHALA3 and IVOR BROWN4

1Division of Biostatistics, University of Rochester Rochester, NY
2Laboratoire of CNS Studies, NINCDS, NIH Bethesda, MD
3Laboratoire de Neurovirologie, Hópital de Ia Salpetriere Paris, France
4Engineering Division, H.R.B. Singer Co. Lanham, MD

Send reprint requests to: Dr. Paul Brown, Building 3G, Room 5B21, NINCDS, NIH, Bethesda, MD 20892.

Raubertas, R. F., P. Brown (NINCDS, NIH, Bethesda, MD 20892), F. Cathala, and I. Brown. The question of clustering of Creutzfeldt-Jakob disease. Am J Epidemiol 1989;129:146–54.

Clustering of Creutzfeldt-Jakob disease has been reported in several countries. The authors review these reports, and they describe their statistical analysis of clustering among 329 cases that died In France during 1968–1982. Paris was found to have a much higher case rate than the rest of France, white some large areas In the north and west had remarkably few cases relative to their populations. No rural clusters were identified. A number of explanations for regional variations in case rates are possible, including population characteristics and case finding artifacts. Based on their results and those of other studies, the authors conclude that the strongest evidence for clustering of Creutzfeldt-Jakob disease is familial and ethnic, rather than geographic.

Creufeldt-Jakob syndrome; space-time clustering


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