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American Journal of Epidemiology Vol. 128, No. 2: 431-438
Copyright © 1988 by The Johns Hopkins University School of Hygiene and Public Health

research-article

AN EPIDEMIOLOGIC STUDY OF CRANIOSYNOSTOSIS: RISK INDICATORS FOR THE OCCURRENCE OF CRANIOSYNOSTOSIS IN COLORADO

BETH W. ALDERMAN1,2, EDWARD J. LAMMER3, SANDRA C. JOSHUA1,2, JOSE F. CORDERO3, DAVID R. OUIMETTE2, MARY J. WILSON3 and STANLEY W. FERGUSON2

1Department of Preventive Medicine and Biometrics, University of Colorado Medical School 4200 East Ninth Avenue, Campus Box C245, Denver, CO 80262
2Division of Disease Control and Epidemiology, Colorado Department of Health Denver, CO
3Birth Defects and Genetic Diseases Branch, Division of Birth Defects and Developmental Disabilities, Center for Environmental Health, Centers for Disease Control, Public Health Service, US Department of Health and Human Services Atlanta, GA

This population-based case-control study was designed to investigate risk indicators for the occurrence of the birth defect craniosynostosis in Colorado. A total of 173 children who underwent craniectomy for craniosynostosis and 759 children without craniosynostosis were included in the study. Multivariable logistic regression analysis of birth certificate data showed that male sex (odds ratio (OR) = 1.6, 95% confidence interval (Cl) = 1.1–2.2), maternal five-year age "increase" (OR = 1.3, 95% Cl = 1.1–1.5), plural birth (OR = 3.0, 95% Cl = 1.2–7.1) and black maternal race (OR = 0.0, 95 per cent Cl = 0.0–0.6) were independ ently associated with craniosynostosis. There was a weak positive association between craniosynostosis and the altitude of the town closest to the maternal residence, but no association was found with maternal education, marital status, number of previous births, or previous pregnancy termination. The association of craniosynostosis with plural birth is consistent with the hypothesis of fetal head constraint.

abnormalities; craniosynostoses; skull


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