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American Journal of Epidemiology Vol. 128, No. 2: 324-336
Copyright © 1988 by The Johns Hopkins University School of Hygiene and Public Health

research-article

LIFE-STYLE RISK FACTORS FOR PANCREATIC CANCER IN LOUISIANA: A CASE-CONTROL STUDY

RONI T. FALK1,, LINDA WILLIAMS PICKLE1, ELIZABETH T. FONTHAM2, PELAYO CORREA2 and JOSEPH F. FRAUMENI, JR.1

1Epidemiology and Biostatistics Program, Division of Cancer Etiology, National Cancer Institute Bethesda, MD
2Pathology Department, Louisiana State University Medical Center New Orleans, LA

Reprint requests to Roni T. Falk, Environmental Epidemiology Branch, National Cancer Institute, Executive Plaza North, Room 430C, Bethesda, MD 20892

A hospital-based, incident case-control study of pancreatic cancer was con ducted between 1979 and 1983 in parallel with similarly designed studies of lung and stomach cancers in high-risk areas of Louisiana. To evaluate life-style practices, including diet, the authors pooled controls from the three studies, and then excluded subjects with diet-altering chronic diseases. When the 363 cases were compared with the 1,234 identified controls, significantly elevated risks were found among persons with Cajun ancestry, especially in rural areas. Among current smokers, a significant twofold risk was associated with moderate (16–25 cigarettes per day) and heavy (≥26 cigarettes per day) consumption, while ex-smokers showed no consistent pattern of risk. After adjustment for potential confounding by smoking, diet, and demographic factors, the risk of pancreatic cancer was unrelated to use of alcoholic beverages or coffee. Pork products and rice were conspicuous as dietary risk factors, each showing a positive dose-response effect, whereas fruit consumption exerted a protective influence.

alcohol drinking; coffee; diet; fruit; pancreatic neoplasms; smoking


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