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American Journal of Epidemiology Vol. 127, No. 6: 1282-1288
Copyright © 1988 by The Johns Hopkins University School of Hygiene and Public Health

research-article

AHAPTOGLOBINEMIA IN AFRICAN POPULATIONS AND ITS RELATION TO MALARIA ENDEMICITY

J. F. TRAPE1, and A. FRIBOURG-BLANC2

1Laboratoire de Paludologie, Centre ORSTOM B.P. 1386, Dakar, Senegal
2Laboratoire d'Lmmunologie 75006 Paris, France

Reprint requests to Dr. J. F. Trape

A study of the relations between plasma haptoglobln levels and malaria endemicity was carried out on selected specimens collected in 1980–1985 during studies on malaria transmission in various populations of the Brazzaville region of the Republic of the Congo. The prevalence of ahaptoglobinemia in schoolchildren is 2.2% in Moungali and 2.9% in Poto-Poto, two districts of Brazzaville where malaria transmission intensity is less than one infective mosquito bite per person per year and malaria prevalence in schoolchildren is less than 10%. In contrast, ahaptoglobinemia prevalence is 48% in schoolchildren from the village of Djoumouna, where malaria transmission intensity reaches 1,000 Infective bites per person per year and malaria prevalence in schoolchildren is 94%. Intermediate values, between 11.1% and 23.4% are observed in schoolchildren from Talangai, Massina, and Linzolo, districts or villages where malaria transmission intensity is between 20 and 250 infective bites per person per year and malaria prevalence in schoolchildren is between 66% and 81%. These findings indicate that ahaptoglobinemia prevalence is correlated with the level of malaria endemicity and provide additional support for the hypothesis that malaria is the main cause of ahaptoglobinemia in African populations. The haptoglobin system may be of considerable Interest in the investigation of the mechanisms of anemia in malaria.

haptoglobins; malaria


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