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American Journal of Epidemiology Vol. 127, No. 5: 990-998
Copyright © 1988 by The Johns Hopkins University School of Hygiene and Public Health

research-article

MENOPAUSE AND OVARIAN CANCER

PATRICIA HARTGE1, ROBERT HOOVER1, LARRY McGOWAN2, LINDA LESHER2 and HENRY J. NORRIS3

1Environmental Epidemiology Branch, National Cancer Institute Bethesda, MD
2Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, George Washington University Medical Center Washington, D.C.
3Armed Forces Institute of Pathology Washington, D.C.

Reprint requests to Dr. Patricia Hartge, NCI, Landow Building, Room 3C06, NIH, Bethesda, MD 20892

Using data from a study of 296 patients diagnosed in greater Washington, D. C., from 1978 to 1981 with primary epithelial ovarian cancer and 343 patients hospitalized for other conditions, the authors estimated the rate ratios according to various characteristics of the menopause. Menopause induced by hysterectomy with preservation of both ovaries was associated with a 30 per cent reduction in risk of later development of ovarian cancer. Age at natural menopause was not consistently related to risk. Women who used menopausal estrogens showed a 40 per cent decreased risk.

estrogens; hysterectomy; menopause; ovarian neoplasms


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