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American Journal of Epidemiology Vol. 127, No. 4: 795-800
Copyright © 1988 by The Johns Hopkins University School of Hygiene and Public Health


research-article

OUTBREAK OF ACUTE HEMORRHAGIC CONJUNCTIVITIS DUE TO COXSACKIE A24 VARIANT—TAIWAN

MENG-YING CHOU1 and MICHAEL D. MALISON2,

1Field Epidemiology Training Program, Department of Health Taipei, Taiwan, Republic of China
2Department of Community Medicine, Emory University, Atlanta, GA, and International Health Program Office, Centers for Disease Control Atlanta, GA

Reprint requests to Dr. Michael D. Malison, International Health Program Office, Centers for Disease Control, Atlanta, GA 30333

Outbreaks of acute hemorrhagic conjunctivitis caused by enterovirus 70 and several serotypes of adenovirus have occurred in Taiwan since 1971. In 1980–1981, there was a pandemic of acute hemorrhagic conjunctivitis in southeast Asia caused by coxsackie A24 variant (CA24v); however, this virus did not affect Taiwan. In October 1985, CA24v was isolated for the first time from patients with acute hemorrhagic conjunctivitis in southern Taiwan. The following summer, a large epidemic of acute hemorrhagic conjunctivitis due to CA24v occurred. An epidemiologic investigation of patients seen at one ophthalmology clinic in Taipei City revealed that school-age children were the most likely group to introduce illness into households (p <0.001) and that males were more often household index cases than were females (p < 0.01). Multiple case households tended to be more crowded (3.0 vs. 2.5 persons per bathroom; p <0.05) and had illness introduced by younger family members (median age of index case = 10 vs. 17 years; p < 0.01). It is unknown whether this outbreak is an isolated occurrence or represents another resurgence of CA24v in the area.

conjunctivitis; acute hemorrhagic; coxsackieviruses; disease outbreaks; eye diseases


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