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American Journal of Epidemiology Vol. 127, No. 4: 734-741
Copyright © 1988 by The Johns Hopkins University School of Hygiene and Public Health

research-article

FORCED VITAL CAPACITY AND THE RISK OF HYPERTENSION

THE NORMATIVE AGING STUDY

DAVID SPARROW1,, SCOTT T. WEISS2, PANTEL S. VOKONAS1,3, L. ADRIENNE CUPPLES4, DAVID J. EKERDT1 and THEODORE COLTON4

1Normative Aging Study, Veterans Administration Outpatient Clinic 17 Court Street, Boston, MA 02108
2Charles A. Dana Research Institute and the Harvard Thorndike Laboratory of the Beth Israel Hospital and Channing Laboratory, Brigham and Women's Hospital, Harvard Medical School Boston, MA.
3Section of Preventive Medicine and Epidemiology and the Evans Memorial Department of Clinical Research, Department of Medicine, University Hospital, Boston University School of Medicine Boston, MA.
4Epidemiology and Biostatistics Section, School of Public Health, Boston University School of Medicine Boston, MA.

Reprint requests to Dr. David Sparrow

This report describes the development of hypertension among 1,270 males (aged 23–80 years at the time of entry into the study) observed prospectively for 10 years who had a baseline blood pressure of less than 140/90 mmHg and who underwent baseline spirometry. Subjects were participants in the Normative Aging Study, a longitudinal study on aging Initiated in 1961 at the Veterans Administration Outpatient Clinic in Boston, Massachusetts. Blood pressures were taken at five- and 10-year follow-up examinations. The age-adjusted incidence of hypertension during the follow-up period was found to be inversely related to forced vital capacity. Multiple logistic regression was employed to assess the relation of forced vital capacity to the subsequent development of hypertension after controlling for baseline levels of age, weight, cigarettes smoked per day, and systolic and diastolic blood pressures. Forced vital capacity was a statistically significant and negative predictor, indicating that lower values of forced vital capacity were associated with the subsequent development of hypertension. This was consistently found in several logistic regression analyses with a stand ardized odds ratio associated with forced vital capacity of approximately 0.7. Afthough the physiologic mechanism for this association is unknown, these findings may have importance in Identifying subjects at risk and may also provide insight into disease pathogenesis.

blood pressure; spirometry


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