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American Journal of Epidemiology Vol. 127, No. 3: 476-487
Copyright © 1988 by The Johns Hopkins University School of Hygiene and Public Health

research-article

A COMPARISON OF THE 12-YEAR MORTALITY AND PREDICTIVE FACTORS OF CORONARY HEART DISEASE AMONG JAPANESE MEN IN JAPAN AND HAWAII

KATSUHIKO YANO1,, CHARLES J. MACLEAN1, DWAYNE M. REED2, YUKIKO SHIMIZU3, HIDEO SASAKI3, KAZUNORI KODAMA3, HIROO KATO3 and ABRAHAM KAGAN1

1Honolulu Heart Program Honolulu, HI
2National Heart, Lung and Blood Institute, Honolulu Heart Program Honolulu, HI
3Radiation Effects Research Foundation Hiroshima, Japan

Reprint requests to Dr. Katsuhiko Yano, Honolulu Heart Program, 347 North Kuakini Street, Honolulu, HI 96817

The mortality and predictive factors of coronary heart disease among men of Japanese ancestry in Japan and Hawaii were compared on the basis of 12 years follow-up data using comparable methods of case ascertainment and risk factor measurements. Among 1,687 men (Japan) and 7,536 men (Hawaii) who were free of coronary heart disease and aged 45–69 at baseline examination In 1965–1968, 20 (Japan) and 123 (Hawaii) cases of fatal coronary heart disease were identified. The age-adjusted mortality rate was 40% higher in Hawaii than in Japan. The difference was not statistically significant, but consistent with earlier studies. More than half of this difference in mortality rate was attributed to different levels of known risk factors in the two cohorts. In multivarlate analysis using the combined population, age, blood pressure, serum cholesterol, serum glucose, cigarette smoking, and alcohol intake (inversely) remained as significant predictors of coronary heart disease mortality. Although the associations of risk factors wtth coronary heart disease tended to be stronger in Hawaii than in Japan, there was no statistically significant difference in regression coefficient for any of the risk factors studied. These findings cannot be claimed to be definitive because of the small number of cases, especially in Japan.

coronary disease; life table methods; mortality; myocardial infarction


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