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American Journal of Epidemiology Vol. 127, No. 3: 454-461
Copyright © 1988 by The Johns Hopkins University School of Hygiene and Public Health

research-article

FIBROADENOMA AND THE USE OF EXOGENOUS HORMONES

A CASE-CONTROL STUDY1

PRISCILLA F. CANNY1,, GERTRUD S. BERKOWITZ2, JENNIFER KELSEY3 and VIRGINIA A. LIVOLSI4

1Department of Epidemiology and Public Health, Yale University School of Medicine P.O. Box 3333, 60 College St., New Haven, CT 06510
2Present affiliation: Departments of Obstetrics, Gynecology, and Reproductive Science, and Community Medicine, Mount Sinai School of Medicine New York, NY
3Present affiliation: Division of Epidemiology, Columbia University School of Public Health New York, NY
4Present affiliation: Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine Philadelphia, PA

Send reprint requests to Dr. Priscilla F. Canny at this address

The association between fibroadenoma and the use of exogenous hormones in women aged 18–74 years was examined in a case-control study conducted in Connecticut during 1979–1981. The study population included 251 women with biopsy-confirmed fibroadenoma and 1,081 control women drawn from inpatient and outpatient general surgical services of five Connecticut hospitals. Among women under age 45 years, oral contraceptive use was negatively associated with the occurrence of fibroadenoma (age-adjusted odds ratio (OR) = 0.57, 95% confidence interval (Cl) = 0.42–0.79). The odds ratio for women over age 45 years who had ever used oral contraceptives was 1.65 (95% Cl = 0.58–4.68). Women over age 45 years who had ever used replacement estrogens had an elevated odds ratio for fibroadenoma (OR = 2.83, 95% Cl = 1.21–6.60). The data suggest either that the effects of exogenous hormones may differ by age, or that the changing composition of exogenous hormones has brought about different associations depending upon the cohort of women.

breast diseases; breast neoplasms; contraceptives, oral; estrogens

1Department of Epidemiology and Public Health, Yale University School of Medicine, P.O. Box 3333, 60 College St., New Haven, CT 06510.


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