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American Journal of Epidemiology Vol. 127, No. 2: 321-336
Copyright © 1988 by The Johns Hopkins University School of Hygiene and Public Health

research-article

PLASMA URIC ACID LEVEL AND ITS ASSOCIATION WITH DIABETES MELLITUS AND SOME BIOLOGIC PARAMETERS IN A BIRACIAL POPULATION OF FIJI

JAAKKO TUOMILEHTO1,, PAUL ZIMMET2, EVA WOLF1, RICHARD TAYLOR3, PARSHU RAM4 and HILARY KING2

1Department of Epidemiology, National Public Health Institute Mannerheimintie 166, SF-00280 Helsinki, Finland
2World Health Organization Collaborating Centre for the Epidemiology of Diabetes Mellitus, The Royal Southern Memorial Hospital, Caulfield South 3162, Victoria, Australia
3South Pacific Commission P. O. Box D5, Noumea Cedex, New Caledonia
4Colonial War Memorial Hospital Suva, Fiji

1Reprint requests to Dr. Jaakko Tuomilehto

Plasma uric acid was Investigated in a population survey on diabetes and cardiovascular risk factors among Melanesians and Asian Indians in Fiji in 1980. Plasma uric acid levels were elevated in men and women with impaired glucose tolerance in both ethnic groups. The lowest plasma uric acid levels were found in diabetic patients, especially in diabetic men. Even though obesity was positively associated with plasma uric acid, it did not explain the high plasma uric acid level in persons with impaired glucose tolerance. Body mass index had a significant and independent impact on plasma uric acid levels both in nondiabetic and diabetic men and women. The strongest predictor of plasma uric acid in the multiple regression analysis in our study populations was plasma creatinlne: It alone explained 9% of the variation in men and 2% in women; and 24% in Melanesians and 5% in Asian Indians. Our findings suggest a strong renal involvement in the balance of plasma uric acid and may also reflect certain dietary patterns, such as a high intake of protein, fats, and certain local vegetables. Although the prevalence of hyperuricemia was high, 27% in both Melanesian men and women, 22% in Asian Indian men, and 11% In Asian Indian women, clinical gout was uncommon. Many predictor variables and their interactions were analyzed along with the reasons for the high plasma uric acid levels in persons with impaired glucose tolerance and for the low plasma uric acid levels in diabetic patients.

creatinine; diabetes mellitus; glucose; hypertension; obesity; rural population; urban population; uric acid


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