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American Journal of Epidemiology Vol. 126, No. 6: 1190-1197
Copyright © 1987 by The Johns Hopkins University School of Hygiene and Public Health

research-article

PHARYNGEAL CARRIAGE AND ACQUISITION OF ANTICAPSULAR ANTIBODY TO HAEMOPHILUS INFLUENZAE TYPE b IN A HIGHRISK POPULATION IN SOUTHWESTERN ALASKA

DAVID B. HALL1,, MILTON K. W. LUM2, LISA R KNUTSON1, WILLIAM L. HEYWARD1 and JOEL I. WARD3

1Arctic Investigations Laboratory, Center for In fectious Diseases, Centers for Disease Control, Public Health Service, Department of Health and Human Services Anchorage, AK
2 Wasila, AK
3Medical Epidemiology Unit and Department of Pediatrics, Harbor-UCLA Medical Center, UCLA School of Medicine Torrance, CA

Reprint requests to David B. Hall, Arctic Investi gations Laboratory, 225 Eagle St., Anchorage, AK 99501

Haemophllus Influenzae type b disease in Alaskan Eskimos Is characterized by greatly Increased disease Incidence at younger ages. This suggests that Eskimo infants have increased exposure to the disease. Exposure was studied in 1982–1983 in children less than age three years who lived in four Eskimo villages, as well as In a random sample of their family members (354 people from 132 households). During a 12-month period, up to four pharyngeal cultures and two serum specimens were obtained from each participant Colonization with H. Influenzae type b was relatively uncommon (overall 2.5% of cultures, 6.8% of individuals) and was not associated with age, sex, season, or prior incidence of disease in the village. Biotyping and outer-membrane-protein typing of H. Influenzae type b isolates revealed homogeneity within villages, with differences between villages. Matched sara revealed a significant decline In H. Influenzae type b capsular antibody in the course of the study year. However, pharyngeal carriage of H. Influenzae type b was associated with increases in antibody for carriers and members of their households. Antibody levels were positively as sociated with age. Only one case of H. Influenzae type b disease developed during the study. Low carriage of H. Influenzae type b was coincident with low incidence of disease and declining levels of capsular antibody in these villages. Mechanisms for increased exposure which would not be reflected in high carriage rates may exist for these young children.

antibodies; carrier state; Eskimos; Haemophllus Influenzae


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