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American Journal of Epidemiology Vol. 126, No. 6: 1103-1114
Copyright © 1987 by The Johns Hopkins University School of Hygiene and Public Health

research-article

BLOOD PRESSURE AND COGNITIVE PERFORMANCE

THE FRAMINGHAM STUDY

MARY E. FARMER1, LON R WHITE1,, ROBERT D. ABBOTT2, STEVEN J. KITTNER3, EDITH KAPLAN4, MICHAEL M. WOLZ1, JACOB A. BRODY5 and PHILIP A. WOLF4

1Epidemiology, Demography, and Biometry Program, National Institute on Aging Bethesda, MD
2Statistical Resource Section, National Heart, Lung, and Blood Institute Bethesda, MD
3Department of Neurology, University of Maryland School of Medicine Baltimore, MD
4Department of Neurology, Boston University School of Medicine Boston, MA
5School of Public Health, University of lllinois at Chicago Chicago, IL

Reprint requests to Dr. Lon R White, Epidemiol ogy, Demography, and Biometry Program, Federal Building, Room 612, National Institute on Aging, Bethesda, MD 20892

In 1976–1978, a battery of eight neuropsychologic tests were administered to 2,123 participants in the Framingham Study who were aged 55–89 years. Performance on each test was examined In relation to concurrently measured systolic and diastolic blood pressure while controlling for age, sex, education, antihypertensive medication, alcohol consumption, and smoking. Those with a diagnosis of stroke were excluded from the analysis. In the remaining sample of 2,032, neither blood pressure nor antihypertensive treatment was significantly associated with cognitive performance. Even after excluding persons on antlhypertensive medication, blood pressure was still unrelated to cognitive performance. in contrast to other studies, the authors found no consistent relation between blood pressure and cognitive performance.

aging; antihypertenslve agents; blood pressure; neuropsychological tests


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