American Journal of Epidemiology Vol. 126, No. 5: 822-830
Copyright © 1987 by The Johns Hopkins University School of Hygiene and Public Health
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FAMILIAL RESEMBLANCE IN THE BLOOD PRESSURE RESPONSE TO SODIUM RESTRICTION
1Departments of Medicine and Medical Genetics, Indiana University School of Medicine Indianapolis, IN
2Department of Medicine, University of Nevada School of Medicine Reno, NV
Reprint requests to Dr. Judy Z. Miller, Hyperten sion Research Center, Indiana University Medical Center, 541 Clinical Drive, Room 409, Indianapolis, IN 46223
Familial resemblance in the blood pressure response to sodium restriction in norrnotensive persons was investigated. Forty-four families of identical twin children participated in a sodium restriction (
75 meq/day) protocol for a period of 12 weeks. Subjects were residents of central Indiana, and the study was conducted over a three-year period. Parent-offspring and sibling-sibling resern blances for actual blood pressure were not different under conditions of ad lib sodium intake versus sodium restriction. Mother-offspring resemblance in blood pressure change with sodium restriction was significant for systolic (p < 0.001), diastolic (p < 0.05), and mean arterial (p < 0.05) pressures. Sibling-sibling and twin-twin resemblances were also highly significant for the change in all three blood pressures. Father-offspring resemblances were marginal (p < 0.10). This study is, to the author's knowledge, the first to demonstrate significant familial resemblances in blood pressure change with sodium restriction in normotensive persons
blood pressure; family; sodium
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