American Journal of Epidemiology Vol. 126, No. 5: 813-821
Copyright © 1987 by The Johns Hopkins University School of Hygiene and Public Health
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THE ASSOCIATION BETWEEN LOW BIRTH WEIGHT AND CAFFEINE CONSUMPTION DURING PREGNANCY
1Perinatal Epidemiology Unit of the Departments of Epidemiology and Public Health, and Obstetrics and Gynecology, Yale University Medical School New Haven, CT.
2Massachusetts Department of Public Health, Division of Health Statistics and Research 150 Tremont Street, 5th floor, Boston, MA 02111
Public Health, Division of Health Statistics and Re search, 150 Tremont Street, 5th floor, Boston, MA 02111. (Reprint requests to Terry R Martin at this address.)
In a prospective study of 3,891 antenatal patients at Yale-New Haven Hospital between 1980 and 1982, 76.7% consumed caffeine from coffee, tea, colas, and drugs. A dose response of caffeine Intake to increased risk for delivering low birth weight (<2,500 9) singleton newborns was observed. This relation was observed in deilvenes after 36 weeks gestatlonal age. When comparison was made with women who had no caffeine exposure, the relative risks of low birth weight after adjustment for confounding factors were 1.4 (95% confidence interval (Cl) 0.7–3.0) for 151–300 mg; of caffeine daily; 2.3 (95% Cl 1.1–5.2) for 151–300 mg; and 4.6 (95% Cl 2.0–10.5) for over 300 mg. Decreases in mean birth weight were 6, 31, and 105 g, respectively. Gestational age did not appear to be related to caffeine consumption in the crude or adjusted analysis. Maternal caffeine intake seems to exert an effect on birth weight through growth retardation In term newborns.
caffeine; delivery; fetal growth retardation; Infant; low birth weight
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