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American Journal of Epidemiology Vol. 126, No. 3: 474-479
Copyright © 1987 by The Johns Hopkins University School of Hygiene and Public Health

research-article

THE CONTROL OF HEPATITIS B VIRUS INFECTION WITH VACCINE IN JAPANESE NURSERY SCHOOLS1

JUN HAYASHI, SEIZABURO KASHIWAGI, HIDEYUKI NOMURA, WATARU KAJIYAMA and HIDEYUKI IKEMATSU

Reprint requests to Dr. Jun Hayashi

Hayashi, J. (First Dept. of Medicine, Kyushu U., Fukuoka, 812, Japan), S. Kash H. Nomura, W. Kajiyama, and H. Ikematsu. The control of hepatitis B virus infection with vaccine in Japanese nursery schools. Am J Epidemiol1987; 126:474-9.

In 1983, the efficacy of an inactivated hepatitis B vaccine was assessed among children in nursery schools in which there was at least one hepatitis B surface antigen-positive child with hepatitis B e antigen. Of the 496 children who com pleted the protocol, 243 (aged 2.7 ± 1.1 years) in six of the nursery schools received three injections of the vaccine. In five other nursery schools, 253 children (aged 2.3 ± 1.0 years) did not receive the vaccine and were used as the control group. No side effects resulted from vaccination. Two doses of the vaccine induced antibodies in 70.8% of the vaccinated children. A booster dose six months after the first induced antibodies in 82.3% of the recipients and markedly increased the proportion of recipients who produced high antibody titiers. Al though nine (4.4%) of the 203 children in the control group (whom the authors were able to follow for 24 months) were infected with hepatitis B virus and two of them became carriers, none of the vaccine recipients were infected. The vaccine appears to be safe, immunogenic, and efficacious in preventing infection with hepatitis B virus in nursery schools.

hepatitis B virus; infection; nurseries; vaccines

1From the First Department of Medicine, Faculty of Medicine, Kyushu University 71, Higashi-Ku, Fukuoka, 812, Japan.


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