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American Journal of Epidemiology Vol. 126, No. 3: 415-428
Copyright © 1987 by The Johns Hopkins University School of Hygiene and Public Health

research-article

GLYCOSYLATED HEMOGLOBIN IN A POPULATION-BASED STUDY OF DIABETES

RONALD KLEIN1,, BARBARA E. K. KLEIN1, SCOT E. MOSS1, EARL S. SHRAGO2 and TERRY L. SPENNETTA2

1Department of Ophthalmology, University of Wisconsin School of Medicine 600 Highland Ave., Madison, WI 53792
2Department of Medicine, University of Wisconsin School of Medicine Madison, WI.

Reprint requests to Dr. Ronald Klein

Klein, R. (Dept. of Ophthalmology, U. of Wisconsin School of Medicine, Madison, WI 53792), B. E. K. Klein, S. E. Moss, E. S. Shrago, and T. L. Spennetta. Glycosylated hemoglobin in a population-based study of diabetes. Am J Epidemiol 1987;126:415-28.

Glycosylated hemoglobin was measured in persons who participated in a population-based study of diabetic retinopathy in southern Wisconsin. There were 996 persons who were diagnosed prior to 30 years of age and who were taking insulin (younger onset), and 1,370 persons who were diagnosed at 30 years of age or older (older onset) who were examined from 1980-1982. Glyco sylated hemoglobin was measured using a microcolumn technique. Mean glyco sylated hemoglobin was highest in younger onset persons (10.9%), and lowest in older onset persons not taking insulin (9.0%). Only a small percentage of values for the diabetic persons fell within the range of values found in a nondi abetic comparison group. Mean glycosylated hemoglobin was found to be asso ciated with retinopathy status but not with proteinuria.

blood glucose; diabetes mellitus; insulin-dependent; diabetes mellitus; non-insulin-dependent; diabetic retinopathy; hemoglobin A; glycosylated; prevalence studies


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