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American Journal of Epidemiology Vol. 126, No. 1: 31-37
Copyright © 1987 by The Johns Hopkins University School of Hygiene and Public Health


research-article

INFECTION WITH HEPATITIS A AND B VIRUSES IN FRENCH VOLUNTEERS WORKING IN TROPICAL AFRICA

B. LAROUZE1,, C. GAUDEBOUT1, E. MERCIER1, G. LIONSQUY2, M. C. DAZZA1, M. ELIAS3, P. GAXOTTE1, J. P. COULAUD1 and J. P. ANCELLE2

1INSERM Unite 13 and Institut de Medecine et d'Epidemiologie Tropicales, Hopital Claude Bernard Paris, France
2Services de Biochimie et de Medecine A, Hopital de Longjumeau Longjumeau, France
3Centre de Transfusion Sanguine, Hopital Bichat Paris, France

Reprint requests to Dr. B. Larouze, INSERM U13, Hopital Claude Bernard, 75944 Paris, Cedex 19, France

The risks of developing hepatitis A and B virus Infections were studied in 233 French volunteers working for 18 to 35 months in the field in West and Central Africa. During their stay in Africa, the seroconverslon rates to antibody to hepatitis A virus of the immunoglobulin G (IgG) class and hepatitis B markers) were 48.1% and 10.5%, respectively; 21.5% of the volunteers developed Jaundice, and 78.0% of the Jaundice cases were associated with hepatitis A seroconverslon, 14.0% with hepatitis B seroconverslon, 4.0% with seroconverslon to both, and 4.0% without seroconversion. Male health workers were at lower risk than other male occupations for hepatitis A infection. Female health workers were at higher risk than other female occupations for hepatitis A Infection. Health workers were at a lower risk of hepatitis B infection, but the significance was borderline. Populations such as these volunteers should receive immunoprophylaxis against hepatitis A and B infections.

hepatitis A; hepatitis B; travel; tropical medicine


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R. Steffen, M. A. Kane, C. N. Shapiro, N. Billo, K. J. Schoellhorn, and P. van Damme
Epidemiology and Prevention of Hepatitis A in Travelers
JAMA, September 21, 1994; 272(11): 885 - 889.
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