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American Journal of Epidemiology Vol. 126, No. 1: 118-126
Copyright © 1987 by The Johns Hopkins University School of Hygiene and Public Health

research-article

A CASE-CONTROL STUDY OF OSTEOSARCOMA IN YOUNG PERSONS

EVA A. OPERSKALSKI1,, SUSAN PRESTON-MARTIN2, BRIAN E. HENDERSON2 and BARBARA R. VISSCHER3

1Department of Medicine, School of Medicine, University of Southern California Los Angeles, CA
2Department of Preventive Medicine, School of Medicine, University of Southern California Los Angeles, CA
3Division of Epidemiology, School of Public Health, University of California Los Angeles, CA

Reprint requests to Dr. Eva A. Operskalski, USC School of Medicine, Edmondson Bldg., Room 111, 1840 North Soto Street, Los Angeles, CA 90032

A study of 64 cases and 124 friend and neighbor controls was conducted to identify factors associated with the occurrence of osteosarcoma in young persons. Two types of information were collected: questionnaire data from telephone interviews with mothers, and data on height since birth from family, physician, and school records. Cases were not taller at the time of diagnosis than controls, nor were growth rates higher—either overall or during the 3–4 years prior to diagnosis. An excess risk, however, was observed among subjects whose birth length was at or below the 25th percentile, based on national standards. An excess risk was also found among subjects bom more than one week early, but the positive association with short birth length remained when duration of pregnancy was taken into account Positive associations were also found for prior trauma to the tumor site; congenital skeletal defects or other treated bone conditions; fetal x-ray, and maternal employment during pregnancy in manufacturing industries.

adolescence; bone neoplasms; child; growth; sarcoma


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