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American Journal of Epidemiology Vol. 125, No. 6: 929-938
Copyright © 1987 by The Johns Hopkins University School of Hygiene and Public Health

research-article

EXPOSURE TO ARSENIC AND RESPIRATORY CANCER A REANALYSIS

PHILIP E. ENTERLINE1,2,, VIVIAN L. HENDERSON2 and GARY M. MARSH1,2

1Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh Pittsburgh, PA 15261
2Center for Environmental Epidemiology, Graduate School of Public Health, University of Pittsburgh Pittsburgh, PA

Reprint requests to Dr. Philip R Enterline

This paper is a reanalysis of data on the respiratory cancer mortality experience of 2,802 men who worked one year or more during the period 1940–1964 at a copper smelter in Tacoma, Washington. Exposure estimates presented earlier have been recalculated and perhaps improved. While the previous analysis showed only a weak relation between respiratory cancer and arsenic exposure, use of new data shows a much stronger relation—but one that is concave downward and not ordinarily considered for environmental exposure and cancer. This new analysis indicates that arsenic is probably more potent as a carcinogen than indicated by other studies. It also demonstrates the distinction between airbome arsenic and the bioavailablility of arsenic, and the importance of this distinction for risk assessment When a dose-response relation is based on airbome concentrations of arsenic, it is clearly concave downward, but when based on urine concentrations, it appears to be linear.

arsenic copper; occupational diseases; respiratory tract neoplasms; risk


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