American Journal of Epidemiology Vol. 125, No. 6: 1019-1034
Copyright © 1987 by The Johns Hopkins University School of Hygiene and Public Health
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VISCERAL LARVA MIGRANS IN FRENCH ADULTS: A NEW DISEASE SYNDROME?
1Section of Epidemiology, Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania 3850 Spruce Street, Philadelphia, PA 19104-6010
2Laboratoire de Parasitologie et d'Ecologie Humaine, Faculte de Medecine Purpan 37 alles Jules-Guesde, 31062 Toulouse Cedex, France
3Institute of Parasitology, University of Zurich Winterthurerstrasse 266a, CH-8057 Zurich, Switzerland
Reprint requests to Dr. Lawrence T. Glickman
Visceral larva migrans is apparently an endemic disease among adults in southwest France. Thirty-seven adults living in the Midi-Pyrenees region of France were confirmed as having visceral larva migrans based on an increased specific antibody titer to Toxocara canis as detected by enzyme-linked immunosorbent assay (ELISA) and by the Western blot method. The disease was characterized clinically by weakness, pruritis, rash, difficulty breathing, abdominal pain, and pathologically by allergic manifestations including eosinophilla and increased serum immunoglobulin (lg) E levels. Conditional logistic regression analysis using a control group of 37 hospital patients with other conditions who were individually matched to patients with visceral larva migrans by age and sex revealed an increased risk for visceral larva migrans associated with hunting or living in a household with a hunter (odds ratio (OR) = 9.0, p = 0.02) and with living in a village of <500 persons (OR = 5.7, p = 0.04). Owning two or more dogs compared with owning one or no dogs increased the risk of visceral larva migrans for hunting or living in a household with a hunter (OR = 9.6 vs. OR = 4.5) and for persons living in nonhunting households (OR = 2.1 vs. OR = 1.0). These findings, however, could not be duplicated when 60 age- and sex-matched neighbors were used as a second control group.
helminths; immunoenzyme technics; larva migrans, visceral; Toxocara; zoonoses
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