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American Journal of Epidemiology Vol. 125, No. 4: 679-689
Copyright © 1987 by The Johns Hopkins University School of Hygiene and Public Health

research-article

PARTITIONING THE VARIABILITY OF FASTING PLASMA GLUCOSE LEVELS IN PEDIGREES

GENETIC AND ENVIRONMENTAL FACTORS

MICHAEL BOEHNKE1,, PATRICIA P. MOLL2,3, BRUCE A. KOTTKE4 and WILLIAM H. WEIDMAN4

1Department of Biostatistics, School of Public Health, The University of Michigan Ann Arbor, MI 48109
2Department of Epidemiology, School of Public Health, The University of Michigan Ann Arbor, MI
3Department of Human Genetics, School of Mothcine, The Umversity of Michigan Ann Arbor, MI
4Mayo Clinic and Mayo Foundation Rochester, MN

Send reprint requests to Dr Michael Boehnke at this address

Fasting plasma glucose measurements made in 1972–1977 on normoglycemic individuals in three-generation Caucasian pedigrees from Rochester, Minnesota were analyzed. The authors determined the contributions of polygenic loci and environmental factors to fasting plasma glucose variability in these pedigrees. To that end, fasting plasma glucose measurements were normalized by an inverse normal scores transformation and then regressed separately for males and females on measured concomitants including age, body mass index (weight/ heightM2), season of measurement, sex hormone use, and diuretic use. The authors found that 27.7% of the variability in normalized fasting plasma glucose in these pedigrees is explained by these measured concomitants. Subsequent variance components analysis suggested that unmeasured polygenic loci and unmeasured shared environmental factors together account for at least an additional 36.7% of the variability in normalized fasting plasma glucose, with genes alone accounting for at least 27.3%. These results are consistent with the known familiality of diabetes, for which fasting plasma glucose level is an important predictor. Further, these familial factors provide an explanation for at least half the variability in normalized fasting plasma glucose which remains after regression on known concomitants.

blood glucose; epidemiologic methods; family; genetics; pedigree; statistics


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