Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (89)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by LAAKSO, M.
Right arrow Articles by MARNIEMI, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by LAAKSO, M.
Right arrow Articles by MARNIEMI, J.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

American Journal of Epidemiology Vol. 125, No. 4: 611-621
Copyright © 1987 by The Johns Hopkins University School of Hygiene and Public Health

research-article

PLASMA INSULIN AND SERUM LIPIDS AND LIPOPROTEINS IN MIDDLE-AGED NON-INSULIN-DEPENDENT DIABETIC AND NON-DIABETIC SUBJECTS

MARKKU LAAKSO1,, KALEVI PYÖRÄLÄ1, ERKKI VOUTILAINEN1 and JUKKA MARNIEMI2

1Department of Medicine, Kuopio University Central Hospital 70210 Kuopio 21, Finland
2Rehabilitation Research Centre of the Social Insurance Institution Turku, Finland

Send reprint requests to Dr. Markku Laakso at this address

The relationship between fasting plasma insulin and serum lipid and lipoprotein levels was studied in 1982–1983 in Kuopio, East Finland in 225 patients with non insulin-dependent diabetes mellitus (119 men and 106 women) and 124 non-diabetic controls (65 men and 59 women). Compared to the non-diabetic controls, diabetic subjects showed significantly lower levels of high density lipoprotein2 (HDL2) cholesterol and high density lipoprotein2 (HDL2) cholesterol and higher levels of total triglycerides and very low density lipoprotein (VLDL) triglycerides. Fasting plasma insulin correlated significantly with total triglycerides and VLDL triglycerides and negatively with HDL cholesterol and HDL cholesterol in both male and female diabetic subjects and non-diabetic control subjects. The correlation between fasting plasma insulin and HDL cholesterol remained statistically significant in non-insulin-dependent diabetic subjects and in female non-diabetic control subjects after adjustment for body mass index, alcohol intake, physical activity, smoking, and fasting plasma glucose. The correlation between fasting plasma insulin and total triglycerides remained significant after adjustment for these variables only in females. By multiple stepwise linear regression analysis, fasting plasma insulin had an independent association with HDL cholesterol in female non-diabetic control subjects and in male diabetic subjects and with triglycerides in female non-diabetic control subjects and in female diabetic subjects. The results show that hyperinsulinemia is related to low HDL cholesterol and HDL2 cholesterol and high total triglycerides and VLDL triglycerides in both non-insulin-dependent diabetic subjects and non-diabetic control subjects. This effect of hyperinsulinemia on lipid and lipoprotein patterns may be one explanation why high plasma insulin can promote accelerated atherosclerosis, particularly in patients with non-insulin-dependent diabetes mellitus.

atherosclerosis; diabetes mellitus; non-insulin-dependent; insulin; lipids; lipoproteins; triglycerides


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Clin. Chem.Home page
A. Brehm, G. Pfeiler, G. Pacini, H. Vierhapper, and M. Roden
Relationship between Serum Lipoprotein Ratios and Insulin Resistance in Obesity
Clin. Chem., December 1, 2004; 50(12): 2316 - 2322.
[Abstract] [Full Text] [PDF]

Home page
 Int J EpidemiolHome page
L. Lauren, M.-R. Jarvelin, P. Elliott, U. Sovio, A. Spellman, M. McCarthy, P. Emmett, I. Rogers, A.-L. Hartikainen, A. Pouta, et al.
Relationship between birthweight and blood lipid concentrations in later life: evidence from the existing literature
Int. J. Epidemiol., October 1, 2003; 32(5): 862 - 876.
[Abstract] [Full Text] [PDF]

Home page
 Arch Intern MedHome page
H.-M. Lakka, T. A. Lakka, J. Tuomilehto, J. Sivenius, and J. T. Salonen
Hyperinsulinemia and the Risk of Cardiovascular Death and Acute Coronary and Cerebrovascular Events in Men: The Kuopio Ischaemic Heart Disease Risk Factor Study
Arch Intern Med, April 24, 2000; 160(8): 1160 - 1168.
[Abstract] [Full Text] [PDF]

Home page
 Int J EpidemiolHome page
F. Al-Mahroos, K. Al-Roomi, and P. M McKeigue
Relation of high blood pressure to glucose intolerance, plasma lipids and educational status in an Arabian Gulf population
Int. J. Epidemiol., February 1, 2000; 29(1): 71 - 76.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
D. L. Rainwater, B. D. Mitchell, M. C. Mahaney, and S. M. Haffner
Genetic Relationship Between Measures of HDL Phenotypes and Insulin Concentrations
Arterioscler. Thromb. Vasc. Biol., December 1, 1997; 17(12): 3414 - 3419.
[Abstract] [Full Text]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
C. M. Burchfiel, R. D. Abbott, D. S. Sharp, J. D. Curb, B. L. Rodriguez, and K. Yano
Distribution and Correlates of Lipids and Lipoproteins in Elderly Japanese-American Men: The Honolulu Heart Program
Arterioscler. Thromb. Vasc. Biol., November 1, 1996; 16(11): 1356 - 1364.
[Abstract] [Full Text]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.