American Journal of Epidemiology Vol. 125, No. 3: 420-436
Copyright © 1987 by The Johns Hopkins University School of Hygiene and Public Health
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PREVALENCE OF ALZIIEIMER'S DISEASE IN A RETIREMENT COMMUNITY
1Department of Neurology, University of California, Irvine Medical Center Orange, CA 92668
2Division of Biostatistics, University of California, Los Angeles School of Public Health Los Angeles, CA
Reprint requests to Dr. R. I. Pfeffer
In a white, predominantly middle class southern California retirement community, 817 adults aged 65–99 years were evaluated in 1980–1982 in a study designed to assess prevalence of early Alzheimer-type senile dementia. Based on 162 neurologically diagnosed cases, the age- and sex-adjusted prevalence of Alzheimer's disease in the target population was 15.3% (95% confidence interval = 13.0–17.5) among persons aged 65+ years and 35.8% among persons aged 80+ years. Age-adjusted correction for false negatives not detected by a screening procedure yields an estimated prevalence of 16.4% in persons aged 65+ years. Validity of the diagnostic approach was confirmed by a follow-up study. These rates far exceed past prevalence estimates for this disease. Since prevalence of mid- and laterstages of Alzheimer's disease may have been underestimated, the high rates in this study may reflect a considerable community burden of early disease. Observed prevalence of Alzheimer-type senile dementia was higher among men than women after adjustment for age, 19.1% and 13.1%, respectively. The female predominance reported in many past clinical surveys may be peculiar to late disease and reflect care-seeking and care-utilization behaviors, rather than differences in incidence.
aged; Alzheimer's disease; community health services; prevalence studies
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