American Journal of Epidemiology Vol. 125, No. 3: 364-372
Copyright © 1987 by The Johns Hopkins University School of Hygiene and Public Health
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RELATION OF OBESITY TO CLUSTERING OF CARDIOVASCULAR DISEASE RISK FACTORS IN CHILDREN AND YOUNG ADULTS
THE BOGALUSA HEART STUDY
1Department of Medicine, Louisiana State University Medical Center New Orleans, LA
2Department of Public Health and Preventive Medicine, Louisiana State University Medical Center New Orleans, LA
3Department of Biometry and Genetics, Louisana State University Medical Center New Orleans, LA
4Department of Biochemistry, Louisiana State University Medical Center New Orleans; LA
Reprint requests to Dr. Gerald S. Berenson, National Research & Demonstration Center—Arteriosclerosis, LSU Medical Center, 1542 Tulane Avenue, New Orleans, LA 70112–2822
The relation of obesity to clustering of systolic blood pressure, fasting insulin, and ratio of low and vely low density lipoprotein cholesterol to high density lipoprotein cholesterol ((LDL-C + VLDL-C)/HDL-C) was investigated in 3,503 subjects aged 5–24 years in Bogatusa, Louisiana, from September 1981 to September 1983. Risk ratios (RR) were calculated as the number of subjects with risk factor variables in the upper tertile divided by the expected number. The variables showed strong clustering (RR = 3.1); however, after adjusting for obesity, clustering of systolic pressure, (LDL-C + VLDL-C)/HDL-C, and insulin was reduced (RR = 1.3). Lean subjects (lower tertile of obesity) showed less clustering than expected (RR = 0.4), while more obese subjects (upper tertile of obesity) had greater clustering than expected (RR = 3.1). Furthermore, trunk fat deposition (subscapular skinfold) had a greater impact on clustering at high levels than limb fat deposition (triceps skinfold). Since obesity is related to clustering of risk factor variables in children and young adults the prevention of the onset of obesity In early life may be important to reducing the risk of coronary heart disease in later life.
atherosclerosis; blood pressure; insulin; lipoproteins; obesity
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