American Journal of Epidemiology Vol. 125, No. 2: 340-347
Copyright © 1987 by The Johns Hopkins University School of Hygiene and Public Health
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EXACT BINOMIAL CONFIDENCE INTERVALS FOR THE RELATIVE RISK IN FOLLOW-UP STUDIES WITH SPARSELY STRATIFIED INCIDENCE DENSITY DATA1
Reprint requests to Dr. Harry A. Guess
The authors present a computer program for hypothesis testing and calculation of exact binomial confidence intervals for the adjusted relative risk in follow-up studies involving multiple strata with incidence density (person-time) denominators and small or zero person-count numerators. The program is an extension to multiple tables of a single-table method by Rothman and Bolce (NIH publication no. 79-1649, Washington, DC: US GPO, 1979) and represents a counterpart for person-time denominators to the program of Thomas (Comput Blomed Res 1975;8:423–46) for exact analysis of multiple tables with person-count denominators. Comparisons with asymptotic analyses of real and simulated data are given. Copies of the program are available from the authors on request.
biometry; epidemiologic methods; follow-up studies; statistics
1Merck Sharp & Dohme Research Laboratories, West Point, PA 19486.
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