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American Journal of Epidemiology Vol. 125, No. 1: 158-162
Copyright © 1987 by The Johns Hopkins University School of Hygiene and Public Health

research-article

SAMPLE SIZE ESTIMATION IN OCCUPATIONAL MORTALITY STUDIES WITH USE OF CONFIDENCE INTERVAL THEORY1

IAN GORDON

In occupational epidemiology, the standardized mortality ratio is firmly entrenched as an analytic too). Sample size determinations have usually been made in a hypothesis testing framework. However, since interval estimation is the usual goal of analysis, it may be more appropriate to use confidence interval theory to estimate the required sample size. This paper gives the method and some resutts for determining the required "expected number" of deaths, based on specifications concerning the confidence interval for the true standardized mortality ratio.

mortality; Poisson distribution

Department of Community Medicine, University of Melbourne, Parkville, Victoria, Australia 3052.


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