American Journal of Epidemiology Vol. 124, No. 2: 306-316
Copyright © 1986 by The Johns Hopkins University School of Hygiene and Public Health
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KAWASAKI SYNDROME: A CONTROLLED STUDY OF AN OUTBREAK IN WISCONSIN
1 Bureau of Community Health and Prevention, Wisconsin Division of Health P.O.Box 309, Madison, WI 53701–0309
2 Department of Entomology, University of Wisconsin Madison, WI
3 Virus Section, Wisconsin State Laboratory of Hygiene Madison, WI
4 Division of Field Services, Epidemiology Program Office, Centers for Disease Control Atlanta, GA
5 Division of Viral Diseases, Center for Infectious Diseases, Centers for Disease Control Atlanta, GA
6Rocky Mountain Laboratories Hamilton, MT
7 Department of Tropical Medicine and Medical Microbiology, John A. Burns School of Medicine, University of Hawaii Honolulu, HI
8 Eudowood Division of Infectious Diseases, Department of Pediatrics, The Johns Hopkins Hospital Baltimore, MD
9 Medical College of Wisconsin Milwaukee, WI
Reprint requests to Dr. Bruce S. Klein
The etiology of Kawasakl syndrome remains unestablished, athough a possible role has been suggested for exposure to the application of carpet shampoo, house dust mites, and rickettsial infection. During an outbreak of 20 cases of Kawasaki syndrome that occurred in southeastern Wisconsin from November 1982 through March 1983, a case-control study was done of 15 cases and 30 matched controls. The study included questionnaire administration, dust collection from homes, and serum specimen collection. Only one patient had been exposed to a shampooed carpet within 30 days before onset of illness. No differences were noted between cases and controls in the degree of exposure to house dust mite-associated factors in the home, nor in the occurrence, density and species-specific prevalence of house dust mites in the home. Meadow voles exposed to house dust mites from the homes of patients did not develop serologic or pathologic evidence of infection due to rickettsiae in the spotted fever and typhus groups or Coxiella burnetil. Anti-mite-specific immunoglobulin E was not detected in serum specimens from cases or controls. Results from this study do not support hypotheses suggesting that the development of Kawasaki syndrome is associated with exposure to application of carpet shampoo, house dust mites, or rickettsial infection.
Kawasaki disease; mites; mucocutaneous lymph node syndrome; rickettsia
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