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American Journal of Epidemiology Vol. 123, No. 6: 1049-1056
Copyright © 1986 by The Johns Hopkins University School of Hygiene and Public Health

research-article

THE RISK OF MYOCARDIAL INFARCTION 10 OR MORE YEARS AFTER VASECTOMY IN MEN UNDER 55 YEARS OF AGE1

LYNN ROSENBERG, PAMELA J. SCHWINGL, DAVID W. KAUFMAN, SUSAN P. HELMRICH, JULIE R PALMER and SAMUEL SHARPIRO

Reprint requests to Dr. Lynn Rosenberg at this address

To evaluate whether vasectomy is associated with a subsequent increase in the incidence of myocardial infarction 10 or more years after surgery and whether an effect is more pronounced in those already predisposed to a myocardial infarction, a hospital-based case-control study was carried out in men aged <55 years. The men were interviewed during 1980–1983 in 78 hospitals in Massachu setts, Rhode Island, Connecticut, and New York. Among 2,238 men with first episodes of myocardial Infarction, 332 (15%) had undergone vasectomy, compared with 572(16%) of 3,361 controls. Vasectomy ≥10 years earlier was reported by 150 cases and 180 controls, to yield a multivariate relative risk estimate of 1.0 after allowance for potential confounding factors (95% confidence interval (Cl) = 0.8–1.3); for vasectomy ≥15 years before, based on 34 cases and 33 controls, the estimate was 1.1 (95% Cl = 0.7–2.0). In men predisposed to myocardial infarction because of more advancedage, cigarette smoking, elevated cholesterol level, hypertension, angina pectoris, or other risk factors, vasectomy did not appear to increase the risk further, even after intervals of ≥10 years. The results provide evidence against an increased risk of myocardial infarction ≥10 years after vasectomy overall and in those known to be predisposed because of other risk factors.

myocardial infraction; vasectomy

1From the Drug Epidemiology Unit, School of Pub-Health, Boston University School of Medicine, Beacon Street, Brookline, MA 02146


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