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American Journal of Epidemiology Vol. 123, No. 5: 800-808
Copyright © 1986 by The Johns Hopkins University School of Hygiene and Public Health

research-article

THE RELATIONSHIP OF BLOOD LEAD TO BLOOD PRESSURE IN A LONGITUDINAL STUDY OF WORKING MEN

S. T. WEISS1,2,, A. MUŅOZ2, A. STEIN2, D. SPARROW3 and F. E. SPEIZER2

1Charles A. Dana Research Institute and the Harvard Thorndike Laboratory of the Beth Israel Hospital, and Department of Medicine, Harvard Medical School Boston, MA
2Channing Laboratory and Department of Medicine, Brigham and Women's Hospital and Harvard Medical School Boston, MA
3Normative Aging Study, VA Outpatient Clinic Boston, MA

Reprint requests to Dr. Scott T. Weiss, Channing Laboratory, Brigham and Women's Hospital, 180 Longwood Avenue, Boston MA 02115

The relationship of lead exposure to blood pressure has been examined in a longitudinal study of a cohort of 89 Boston, Massachusetts, policemen. At the baseline examination, subjects had a blood lead determination and three consecutive blood pressure measurements. Triplicate blood pressure measurements were also taken at years 3, 4, and 5. Multivariate analysis revealed that, after correction for previous systolic blood pressure, body mass index, age, and smoking, a high level of blood lead was a significant predictor of subsequent elevation of systolic pressure. Bootstrap simulations of these models provided supporting evidence for the observed associations. These data suggest that lead exposure can significantly affect systolic pressure.

blood pressure; hypertension; lead; longitudinal studies


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