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American Journal of Epidemiology Vol. 122, No. 6: 982-993
Copyright © 1985 by The Johns Hopkins University School of Hygiene and Public Health

research-article

MENOPAUSAL CHANGE IN SERUM CHOLESTEROL BLACK/WHITE DIFFERENCES IN EVANS COUNTY, GEORGIA

DONNA DAY BAIRD1 , HERMAN A. TYROLER1,, GERARDO HEISS1, LLOYD E. CHAMBLESS2 and CURTIS G. HAMES3

1Department of Epidemiology, School of Public Health, University of North Carolina Chapel Hill, NC 27514
2Department of Biostatistics, School of Public Health, University of North Carolina Chapel Hill, NC
3 Hames Clinic, Claxton, GA

Reprint requests to Dr. Herman A. Tyroler

The relationship between menopausal status and total serum cholesterol was examined cross-sectionally in a population of 40- to 54-year-old black and white women of Evans County, Georgia. The relationship differed in blacks and whites as assessed by a significant interaction term in linear regression. Controlling for age, Quetelet index, and smoking status, white postmenopausal women showed an estimated increase in total serum cholesterol of 25 mg/dl (p<0.001) compared with premenopausal whites, whereas black postmenopausal women showed no significant increase in total serum cholesterol compared with premenopausal blacks. The authors were unable to atttibute the lack of menopausal effect in blacks to selection or measurement bias, nor did confounding or effect modification by obesity or social status negate their findings. Of six other populations in which menopausal influence on total serum cholesterol has been examined, only Pima Indians failed to show a significant increase.

cholesterol; menopause; obesity

Current address for Dr. Baird: Epidemiology Branch, NIEHS, Research Triangle Park, NC 27709.


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