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American Journal of Epidemiology Vol. 122, No. 5: 820-829
Copyright © 1985 by The Johns Hopkins University School of Hygiene and Public Health

research-article

GALLBLADDER DISEASE EPIDEMIOLOGY IN MEXICAN AMERICANS IN STARR COUNTY, TEXAS

CRAIG L. HANIS1,, ROBERT E. FERRELL1,2, BRIAN R. TULLOCH3 and WILLIAM J. SCHULL1

1Center for Demographic and Population Genetics, Graduate School of Biomedical Sciences, University of Texas Health Science Center at Houston Houston, TX
2Current addressDepartment of Biostatistics, Graduate School of Public Health, University of Pittsburgh Pittsburgh, PA
3Diagnostic Clinic of Houston Houston, TX

Reprint requests to Dr. Craig L. Hanis, Center for Demographic and Population Genetics, University of Texas Health Science Center at Houston, P.O.Box 20334, Houston, TX 77225

The prevalence of gallbladder disease (surgery or complaints) among Mexican Americans in Starr County, Texas, is demonstrated to be some threefold higher than in Framingham, with 13% and 26% of males and females, respectively, over the age of 35 years having the disease. The population aggregation of gallbladder disease in Amerindian groups and those genetically admixed with them (as the present case) is consistent with an underlying genetic mechanism which is further substantiated here by examining relative risks in sibs, offspring, and spouses of individuals with gallbladder disease. It is shown that in females under the age of 45 years, there is evidence for a significant association between gallbladder disease and diabetes beyond that which could be explained by body mass. Significant gallbladder disease by nonlinear age interaction effects was detected for serum cholesterol. The predicted regression lines of cholesterol by age were uniformly lower for individuals with gallbladder disease than those without it except for ages 40–55 years, in which the lines were equal. When coupled with previous results on diabetes, the results presented document the extent to which diabetes and gallbladder disease dominate the health status of Mexican Americans in southern Texas and likely elsewhere.

cholelithiasis; cholesterol; diabetes mellitus; gallblader diseases; Mexican Americans; population; prevalence studies


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