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American Journal of Epidemiology Vol. 122, No. 4: 673-683
Copyright © 1985 by The Johns Hopkins University School of Hygiene and Public Health

research-article

MORTALITY OF LEAD SMELTER WORKERS

SHERRY G. SELEVAN1,, PHILIP J. LANDRIGAN1, FRANK B. STERN1 and JAMES H. JONES2

1Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, Centers for Disease Control Cincinnati, OH
2Division of Physical Sciences and Engineering, National Institute for Occupational Safety and Health Cincinnati, OH

Reprint requests to Dr. Sherry G. Selevan, Office of Research and Development, US Environmental Protection Agency, Washington, DC 20460

To examine patterns of death in lead smelter workers, a retrospective analysts of mortality was conducted in a cohort of 1,987 males employed between 1940 and 1965 at a primary lead smelter in idaho. Overall mortality was similar to that of the United States white male population (standardized mortality ratio (SMR)=98). Excess mortality, however, was found from chronic renal disease (SMR=192; confidence interval (Cl)=88–364), and the risk of death from renal disease increased with increasing duration of employment, such that after 20 years employment, the standardized mortality ratio reached 392 (Cl=107–1,004). Excess mortality was also noted for nonmalignant respiratory disease (SMR=187, Cl=128–264). Eight of 32 deaths in this category were caused by silicosis; at least five workers who died of silicosis had been miners for a part of their lives. An additional 11 deaths resulted from tuberculosis (SMR=139; Cl=69–249); in six of these cases, silicosis was a contributory cause of death. Cancer mortality was not increased overall (SMR=95; Cl=78–114). An increase, however, was noted for deaths from kidney cancer (six cases; SMR=204; Cl=75–444). Finally, excess mortality was noted for injuries (SMR=138; Cl=104–179); 13 (23%) of the 56 deaths in this category were caused by mining injuries. The data from this study are consistent with previous reports of increased mortality from chronic renal disease in persons exposed occupationalry to lead.

kidney neoplasms; lead; nephritis; nephrosis; silicosis


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