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American Journal of Epidemiology Vol. 122, No. 3: 386-390
Copyright © 1985 by The Johns Hopkins University School of Hygiene and Public Health

research-article

FAMILIAL AGGREGATION OF RED BLOOD CELL CATION TRANSPORT SYSTEMS IN JAPANESE FAMILIES

SADANOBU KAGAMIMORI, YUCHI NARUSE, MASANOBU TAKATA, TAKAKO FUJITA and MASAO WATANABE

Department of Community Medicine, Faculty of Medicine, Toyama Medical and Pharmaceutical University 2630 Sugitani, Toyama City 930-01, Japan

Send reprint requests to Dr. Kagamimori.

The rate of lithium, sodium, and potassium transport in red blood cells is thought to be associated with essential hypertension. In order to investigate the contribution of genetic and environmental factors to cation transport, their correlation was analyzed in 60 parent-offspring pairs and 17 husband-wife pairs in Toyama City, Japan. Lithium-sodium countertransport and sodium-potassium cotransport rates were significantly correlated in parent-offspring pairs (r=0.52, p<0.01 and r=0.46, p <0.01, respectively) but not in husband-wife pairs. Sodium pump rates were significantly correlated in both pairs (r=0.48, p<0.01 in parent-offspring pairs, r=0.46, p<0.05 in husband-wife pairs). Therefore, lithium-sodium countertransport and sodium-potassium cotransport were found to have a substantial genetic component and the sodium pump to have a substantial environmental component Sodium pump rates were significantly correlated with sodium/creatinine (r=0.21, p<0.05) and sodium/potassium (r=0.32, p<0.01) in casual urine.

cations; erythrocytes; family


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