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American Journal of Epidemiology Vol. 122, No. 1: 163-186
Copyright © 1985 by The Johns Hopkins University School of Hygiene and Public Health

research-article

PERMUTATION METHODS FOR THE STRUCTURED EXPLORATORY DATA ANALYSIS (SEDA) OF TOTAL CHOLESTEROL MEASURED IN FIVE ISRAELI POPULATIONS

SAMUEL KARLIN1, PAUL T. WILLIAMS2, DORIT CARMELLI3 and EDWARD CAMERON 4

1Department of Mathematics, Stanford University Stanford, CA 94305
2Stanford Heart Disease Prevention Program 730 Welch Road, Palo Alto, CA
3Department of Behavioral Medicine, SRI International Menlo Park, CA

Reprint requests to Dr. Samuel Karlin

Three structured exploratory data analysis-functionals are applied to plasma total cholesterol concentrations measured for 2,480 young men and women aged 17–18 years and living in Jerusalem, and for their parents. These triad families are divided into five groups according to whether both parents were born in Asia, North Africa, Europe-America, or Israel or whether they were of mixed "origins." The significances of the functionals were determined by a spectrum of permutation techniques that selectively shuffled the trait values across families in order to systematically alter certain family structure relationships while keeping other familial relationships intact These analyses suggest that generational differences and various distributional effects influence patterns of spouse and parent-offspring interactions within these families and that the nature and forms of these effects and interactions may differ according to the origin of the parents. Results are discussed in relationship to historical and cultural differences among groups.

cholesterol; family characteristics; genetics; statistics

4Deceased.


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