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American Journal of Epidemiology Vol. 121, No. 5: 712-719
Copyright © 1985 by The Johns Hopkins University School of Hygiene and Public Health

ORIGINAL CONTRIBUTIONS

RISK FACTORS FOR EARLY NEONATAL SEPSIS

MICHAEL SOMAN1, BEVERLY GREEN1 and JANET DALING2

1 Robert Wood Johnson Faculty Development Fel lowship Program, Department of Family Medicine, University of Washington Seattle, WA
2 Department of Epidemiolo School of Public Health, University of Washington Seattle, WA

Reprint requests to Dr. Michael Soman, Depart ment of Family Medicine, Research Section, HQ-30, University of Washington, Seattle, WA 98195

Received for publication March 30, 1984. Revision received July 23, 1984. The authors undertook a case-control study of 113 cases of neonatal sepsis and 347 randomly selected controls. All cases and controls were selected from the 1980 and 1981 Washington State birth certificates. The increased risk for males (odds ratio (OR) = 1.75, p = 0.012) and the large risk associated with low birth weight (OR = 99.1, p <0.001 if <1,500 g and OR = 5.17, p < 0.001 if 1,500– 2,500 g) are consistent with past studies. The relationship of maternal age (OR = 2.00, p = 0.01 if 20 years and OR = 1.74, p = 0.05 If >30) parallels the overall risk of many pregnancy-related complications in these age groups. Interpretation of the elevated risk associated with amniocentesis is hampered by small numbers but is provocative. The strong association of an Apgar score of 6 or less at five minutes (OR = 36.25, p <0.001) with neonatal sepsis suggests the possibility of routine sepsis evaluation in such neonates born in areas with high incidence rates of early neonatal sepsis. We found no previous reports associating either abrupilo placentae (OR = 12.70, p = 0.028) or preeclampsia (OR = 6.43, p = 0.017) with neonatal sepsis.

infant, low birth weight; infant, newborn, diseases; septicemia


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