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American Journal of Epidemiology Vol. 121, No. 5: 675-683
Copyright © 1985 by The Johns Hopkins University School of Hygiene and Public Health


ORIGINAL CONTRIBUTIONS

A CASE-CONTROL INQUIRY INTO THE ETIOLOGY OF HAIRY CELL LEUKEMIA

DENISE OLESKE1, HARVEY M. GOLOMB2, MARILYN D. FARBER2 and PAUL S. LEVY3

1 Hematology/Oncology Section, University of Chicago Chicago, IL.
2 Department of Ophthalmology, University of Illinois Chicago, IL.
3 Epidemiology and Biometry Program, School of Public Health, Universityof Illinois Chicago, IL.

Reprint requests to Dr. Denise Oleske, Hematol ogy/Oncology Section, University of Chicago, Box 420, 5841 S. Maryland, Chicago, IL 60637

Received for publication July 6, 1984. Revision received September 11, 1984. Oloske, D. (Hematology/Oncology Section, U. of Chicago, Chicago, IL 60637), H. M. Golomb, M. D. Farber, and P. S. Levy. A case-control inquiry into the etiology of hairy cell leukemia. Am J Epidemiol 1985;121:675–83.

A case-control study was conducted to investigate the etiology of hairy cell leukemia. Forty-five individuals with histologically confirmed hairy cell leukemia comprised the cases. Three neighborhood controls were selected on the basis of age (±5 years), race, sex, and residence at the time of the interview for each case. There was no association found for cigarette smoking, alcohol or coffee consumption and hairy cell leukemia. With respect to occupational risk factors, employment in woodworking or in farming was of borderline significance. Re ported exposure to organic chemicals in the workplace was significantly greater among both sexes of the cases than among their respective matched controls (relative risk (RR) = 3.10). Other variables found to be significantly associated with hairy cell leukemia wore farm birthplace (RR = 4.20), anemia (RR = 4.29), migraine (RR = 4.80), Infectious mononucleosis (RR = 9.00), and routine use of aspirin (RR = 3.41) or tranquilizers (RR = 4.50). No association between radiation and hairy cell leukemia was detected.

hematologic diseases; leukemia; leukemia; hairy cell


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