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American Journal of Epidemiology Vol. 121, No. 3: 440-447
Copyright © 1985 by The Johns Hopkins University School of Hygiene and Public Health

research-article

AN EPIDEMIOLOGIC STUDY OF FIBROCYSTIC BREAST DISEASE WITH REFERENCE TO DUCTAL EPITHELIAL ATYPIA

HARRIS PASTIDES1,, JENNIFER L. KELSEY2, THEODORE R. HOLFORD3 and VIRGINIA A. LIVOLSI4

1Division of Public Health, University of Massachusetts School of Health Sciences Amherst, MA 01003
2Division of Epidemiology, Columbia University School of Public Health New York, NY
3Department of Epidemiology and Public Health, Yale University, School of Medicine New Haven, CT
4Department of Pathology, University of Pennsylvania School of Medicine Pennsylvania, PA

Reprint requests to Dr. Harris Pastides

A case-control study of 255 women with fibrocystic breast lesions and 790 controls was conducted at two hospitals in New Haven, Connecticut during 1977–1979. Cases were found to weigh significantly less than controls, and were more likely than controls to have: a first-degree female relative with a history of breast cancer a higher level of education; a recent history of regular gynecologic checkups; and (if under age 45 years) a later ago at first pregnancy. They were less likely to have had a surgical menopause. The degree of ductal epithelial atypia in breast biopsy specimens was evaluated in order to see whether epidemiologic characteristics differed according to the degree of ductal atypia. The only variable to show a linear relationship with ductal atypia was a recent history of regular gynecologic checkups; those with no or minimal atypia were more likely to have had recent checkups than those with high atypia scores. This study thus gives no evidence that known risk factors for breast cancer are more strongly associated with fibrocystic breast disease with a high degree of atypia than with fibrocystic breast disease with a low degree of atypia. It also provides data to support the belief that women having frequent gynecologic checkups are more likely to be included as cases in case-control studies of fibrocystic breast disease, and particularly in the groups with no or minimal atypia, than those not having frequent checkups.

fibrocystic disease of breast; ductal atypia


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