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American Journal of Epidemiology Vol. 121, No. 3: 414-421
Copyright © 1985 by The Johns Hopkins University School of Hygiene and Public Health

research-article

A CASE-CONTROL STUDY OF DEMENTIA OF THE ALZHEIMER TYPE

L. RONALD FRENCH1 2, LEONARD M. SCHUMAN1, JAMES A. MORTIMER3, J. THOMAS HUTTON4, RUBY A. BOATMAN1 and BONNA CHRISTIANS1

1Division of Epidemiology, School of Public Health, University of Minnesota Minneapolis, MN
3Geriatric Research Evaluation and Clinical Center, Veterans Administration Medical Center Minneapolis, MN Department of Neurology, University of Minnesota Minneapolis, MN
4Department of Medical and Surgical Neurology, School of Medicine, Texas Tech University Lubbock, TX

Send reprint requests to: Division of Epidemiology, School of Public Health, University of Minnesota, 1360 Mayo Memorial Building, 420 Delaware St. SE, Minneapolis, MN 55455

A case-control study to assess factors of possible etiologic significance to dementia of the Alzheimer type was conducted with 78 male cases diagnosed in 1979–1982 at the Veterans Administration Medical Center in Minneapolis, Minnesota and age-race-sex-matched hospital and neighborhood controls (14 of 16 autopsied cases were histopathologically confirmed). Information was obtained on variables relevant to viral, genetic, and immunologic hypotheses, and on possible occupational and environmental exposures, drug use, pychologic stress, smoking, and alcohol consumption. The only major difference between patients with dementia of the Alzheimer type and controls was a significantly greater occurrence of antecedent head trauma in the patients (odds ratio=4.50). This finding is consistent with the literature on posttraumatic dementia but its importance is presently unclear.

aging; Alzheimer's disease; dementia, presenile; dementia, senile

2Current Address: Chronic Disease Epidemiology Section, Disease Prevention and Control Division, Minnesota Department of Health, Minneapolis, MN.


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