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American Journal of Epidemiology Vol. 121, No. 1: 65-70
Copyright © 1985 by The Johns Hopkins University School of Hygiene and Public Health

research-article

DIETARY VITAMIN A DEFICIENCIES AND STOMACH CANCER

PAUL A. STEHR1,2, MARGARET F. GLONINGER1, LEWIS H. KULLER1, GARY M. MARSH3, EDWARD P. RADFORD4 and GENE B. WEINBERG5

1Department of Epidemiology, University of Pittsburgh Pittsburgh, PA.
2Current address: Center for Environmental Health, Centers for Disease Control Atlanta, Georgia 30333. (Reprint requests to Dr. Stehr.)
3Department of Biostatistics, University of Pittsburgh Pittsburgh, PA
4Radiation Effects Research Foundation Hiroshima City, Japan
5Pennsylvania Department of Health Harrisburg, PA

The hypothesis of vitamin A intake deficiencies serving as an antecedent factor in the development of stomach cancer was assessed employing a case-control design. Interviews of proxy informants for 111 cases and a pair-matched control group were conducted using a food frequency questionnaire from which an averaged vitamin A Intake index was calculated. Stomach cancer cases showed a significantly higher proportion with lowered total vitamin A Intake levels (odds ratio = 1.71) which remained constant across sex and socioeconomic status groupings. These results demonstrated a consistency with previous related studies vis-à-vis the strength and specificity of the putative association, a moderate (but statistically nonsignificant) dose-response curve, proper temporal association, and biologic plausibility.

diet; neoplasms; stomach; vitamin A


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