American Journal of Epidemiology Vol. 121, No. 1: 31-36
Copyright © 1985 by The Johns Hopkins University School of Hygiene and Public Health
research-article |
CONGENITAL HEART DISEASE: PREVALENCE AT LIVEBIRTH
THE BALTIMORE-WASHINGTON INFANT STUDY
1Department of Epidemiology and Preventive Medicine, University of Maryland School of Medicine 655 W. Baltimore Street, Baltimore, MD 21201. (Reprint requests to Dr. C. Ferencz.)
2Division of Pediatric Cardiology, Department of Pediatrics, University of Maryland School of Medicine Baltimore, MD
3Division of Pediatric Cardiology, Department of Pediatrics, Johns Hopkins University School of Medicine Baltimore, MD
4Cardiology Department, Children's Hospital National Medical Center, George Washington University School of Medicine Washington, DC
5Division of Pediatric Cardiology, Department of Pediatrics, Georgetown University School of Medicine Washington, DC
6Division of Pediatric Cardiology, Department of Pediatrics and Child Health, Howard University School of Medicine Washington, DC
The Baltimore-Washington Infant Study is a regional epidemiologic study of congenital heart disease. Among infants born in the study area in 1981 and 1982, 664 had a diagnosis of congenital heart disease confirmed in the first year of life by echocardiography, cardiac catheterization, cardiac surgery, or autopsy. The prevalence rate was 3.7/1,000 livebirths for all cases and 2.4/1,000 livebirths for cases confirmed by invasive methods only. Diagnosis-specific prevalence rates of congenital heart disease are compared with those of eight previous case series. Changing diagnostic categorizations in the time span covered and methodological differences resulted in great variation of the data. However, the data of the New England infant Cardiac Program which used the same case discovery methods showed similar occurrences of major morphologic abnormalities, suggesting that these are stable basic estimates in the eastern United States. For all case series, the rate of confirmed congenital heart disease was approximately 4/1,000 livebirths over the 40-year time span.
epidemiologic methods; health services; heart defects, congenital; infant
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|
|
|
|
|
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|
|
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|
|
|
|
 |
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|
|
|
|
|
|
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|
|
|
|
 |
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
A. J. J. T. Rein, S. l. Omokhodion, and A. Nir Significance of a Cardiac Murmur as the Sole Clinical Sign in the Newborn Clinical Pediatrics, September 1, 2000; 39(9): 511 - 520. [Abstract] [PDF]
|
|
|
|
|
|
C Wren, S Richmond, and L Donaldson Temporal variability in birth prevalence of cardiovascular malformations Heart, April 1, 2000; 83(4): 414 - 419. [Abstract] [Full Text]
|
|
|
|
 |
|
 V. Grech Patent Ductus Arteriosus in a Population-Based Study Asian Cardiovasc Thorac Ann, December 1, 1999; 7(4): 301 - 304. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Breymann, G. Kirchner, U. Blanz, E. Cherlet, H. Knobl, H. Meyer, R. Korfer, and W.-R. Thies Results after Norwood procedure and subsequent cavopulmonary anastomoses for typical hypoplastic left heart syndrome and similar complex cardiovascular malformations Eur. J. Cardiothorac. Surg., August 1, 1999; 16(2): 117 - 124. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C Tennstedt, R Chaoui, H Korner, and M Dietel Spectrum of congenital heart defects and extracardiac malformations associated with chromosomal abnormalities: results of a seven year necropsy study Heart, July 1, 1999; 82(1): 34 - 39. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Yeh Jr, M. S. Connelly, J. G. Coles, G. D. Webb, P. R. McLaughlin, R. M. Freedom, P. B. Cerrito, and W. G. Williams ATRIOVENTRICULAR DISCORDANCE: RESULTS OF REPAIR IN 127 PATIENTS J. Thorac. Cardiovasc. Surg., June 1, 1999; 117(6): 1190 - 1211. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Hyett, M. Perdu, G. Sharland, R. Snijders, and K. H Nicolaides Using fetal nuchal translucency to screen for major congenital cardiac defects at 10-14 weeks of gestation: population based cohort study BMJ, January 9, 1999; 318(7176): 81 - 85. [Abstract] [Full Text]
|
|
|
|
|
|
S. B Ainsworth, J. P Wyllie, and C. Wren Prevalence and clinical significance of cardiac murmurs in neonates Arch. Dis. Child. Fetal Neonatal Ed., January 1, 1999; 80(1): 43F - 45. [Abstract] [Full Text]
|
|
|
|
|
|
J. Gregory, A. Emslie, J. Wyllie, and C. Wren Examination for cardiac malformations at six weeks of age Arch. Dis. Child. Fetal Neonatal Ed., January 1, 1999; 80(1): 46F - 48. [Abstract] [Full Text]
|
|
|
|
|
|
C. Wren, S. Richmond, and L. Donaldson Presentation of congenital heart disease in infancy: implications for routine examination Arch. Dis. Child. Fetal Neonatal Ed., January 1, 1999; 80(1): 49F - 53. [Abstract] [Full Text]
|
|
|
|
|
|
J. Soongswang, I. Adatia, C. Newman, J. F. Smallhorn, W. G. Williams, and R. M. Freedom Mortality in potential arterial switch candidates with transposition of the great arteries J. Am. Coll. Cardiol., September 1, 1998; 32(3): 753 - 757. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Atalay, A. Imamoglu, L. Dilek, N. Altug, E. Tutar, and H. Gumus Congenital Isolated Apical Ventricular Septal Defects Angiology, May 1, 1998; 49(5): 355 - 359. [Abstract] [PDF]
|
|
|
|
 |
|
 C. A. Eisenberg and D. M. Bader Establishment of the Mesodermal Cell Line QCE-6 : A Model System for Cardiac Cell Differentiation Circ. Res., February 1, 1996; 78(2): 205 - 216. [Abstract] [Full Text]
|
|
|
|
|
|
S. S. Karr, J. I. Brenner, C. Loffredo, C. A. Neill, and J. D. Rubin Tetralogy of Fallot: The Spectrum of Severity in a Regional Study, 1981-1985 Arch Pediatr Adolesc Med, January 1, 1992; 146(1): 121 - 124. [Abstract] [PDF]
|
|
|
|
|
|
K. A. Berg, J. A. Astemborski, J. A. Boughman, and C. Ferencz Congenital Cardiovascular Malformations in Twins and Triplets From a Population-Based Study Arch Pediatr Adolesc Med, December 1, 1989; 143(12): 1461 - 1463. [Abstract] [PDF]
|
|
|
|
|
|
J. I. Brenner, K. A. Berg, D. S. Schneider, E. B. Clark, and J. A. Boughman Cardiac Malformations in Relatives of Infants With Hypoplastic Left-Heart Syndrome Arch Pediatr Adolesc Med, December 1, 1989; 143(12): 1492 - 1494. [Abstract] [PDF]
|
|
|
|
|
|
D. S. Schneider, K. G. Zahka, E. B. Clark, and C. A. Neill Patterns of Cardiac Care in Infants With Down Syndrome Arch Pediatr Adolesc Med, March 1, 1989; 143(3): 363 - 365. [Abstract] [PDF]
|
|
|
|
|
|
J. D. Rubin, C. Ferencz, J. I. Brenner, C. A. Neill, and L. W. Perry Early Detection of Congenital Cardiovascular Malformations in Infancy Arch Pediatr Adolesc Med, November 1, 1987; 141(11): 1218 - 1220. [Abstract] [PDF]
|
|
|
|
|
|
H.-H. Kramer, F. Majewski, H. J. Trampisch, S. Rammos, and M. Bourgeois Malformation Patterns in Children With Congenital Heart Disease Arch Pediatr Adolesc Med, July 1, 1987; 141(7): 789 - 795. [Abstract] [PDF]
|
|