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American Journal of Epidemiology Vol. 121, No. 1: 116-119
Copyright © 1985 by The Johns Hopkins University School of Hygiene and Public Health

research-article

HEPATITIS A ANTIBODIES: PREVALENCE AND PERSISTENCE IN A GROUP OF MEXICAN CHILDREN

JUAN RUIZ-GOMEZ1 and MA. ELENA BUSTAMANTE-CALVILLO1

1Virology Laboratory, Hospital de Pedistria, Centro Médico Nacional, Instituto Mexicano del Seguro Social, Av. Cuantémoc No. 330 Colonia Doctores, Mexico City, Mexico. (Reprint requests to Dr. J. Ruiz-Gômez.)

The prevalence of antibodies against hepatitis A virus (anti-HAV) was evaluated in sera from 275 asymptomatic infants and children under the age of five years and in 46 maternal-cord serum pairs, followed by sera obtained thereafter each month from the first to the fifth month of life in 29, 17, 9, 9 and 7 infants (a total of 163 serum samples). Anti-HAV was found in all cord blood sera, but its prevalence declined progressively to 0% among 19 infants aged eight months. Four (25%) of 16 children aged one year had positive anti-HAV and the antibody prevalence was 89% in children five years old. Recent hepatitis A infection shown by circulating anti-HAV immunoglobulin M was detected in five infants under the age of two months and with frequencies ranging from 19–67% in one- and five- year-old children. It was concluded that in children living in Mexico City, hepatitis A infections occur at an earlier age and at higher rates than in children in other cities, especially those in developed countries.

antibodies; hepatitis A virus; pediatrics


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