American Journal of Epidemiology Vol. 121, No. 1: 11-18
Copyright © 1985 by The Johns Hopkins University School of Hygiene and Public Health
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HYPERURICEMIA AS A RISK FACTOR OF CORONARY HEART DISEASE: THE FRAMINGHAM STUDY
1Boston University School of Medicine, Evans Research Foundation Boston, MA
2Framingham Heart Study, National Heart, Lung, and Blood Institute Framingham, MA
Reprint requests to Dr. F.N. Brand, Boston University School of Medicine, Evans Research Foundation, Boston, MA 02118
Uric acid values were obtained on subjects of the original Framingham cohort at their fourth and 13th biennial examinations. The mean uric acid value for men was 5.0 mg/dl at the fourth examination and 5.7 mg/dl at examination 13 and was 3.9 mg/dl and 4.7 mg/dl, respectively, for women. This secular trend was due to both "laboratory drift" and increasing use of diuretics. Serum uric acid values were consistently higher in subjects of both sexes who were taking antihypertensive drugs at both examinations. Serum uric acid values correlated with systolic and diastolic blood pressure in both sexes; the relationship was stronger in women than in men and for systolic than for diastolic pressure. Correlations were stronger at examination 4 than at examination 13 when more antlhypertensive treatment was used. ExaminatIon 4 serum uric acid predicted the subsequent development of coronary heart disease, in general, and myocardial infarction, in particular, but not angina pectorts. The uric acid relationship with myocardial infarction was equally strong in both sexes, even correcting for antlhypertensive treatment However, in multivarlate analysis, Including age, systolic blood pressure, relative weight, cigarette smoking, and serum cholesterol, serum uric acid did not add independently to the prediction of coronary heart disease.
cardiovascular system; coronary disease; uric acid
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